The Pamir Highway is one of the world’s greatest road trips. The Pamir Highway. It’s a name that vibrates strongly in the belly of anyone with a taste for adventure. The high desert of the Pamir invites expletives and superlatives. ... It crosses the whole Pamir region of Tajikistan, running from Dushanbe to Khorog to Osh. From this road, you can look at China, peek into Pakistan and wave to villagers in Afghanistan.